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Vets identify gene responsible for feline tooth resorption
The discovery follows an analysis of genetic material recovered from the teeth of 11 cats.
Blocking activity of the MMP9 gene could prevent condition from developing.

A team of vets at the University of Edinburgh's Royal (Dick) School of Veterinary Studies say they have identified a gene responsible for causing feline tooth resorption - a common condition estimated to affect 20 to 60 per cent of all cats.

The discovery follows an analysis of genetic material recovered from the teeth of 11 cats, with permission of the animals' owners. Vets found more than 1,000 genes that had been active in teeth where resorption had occurred and therefore might be involved in the process. 

The team concentrated on one particular gene - the MMP9 gene - which produces a protein commonly found in areas of damaged tissue. In experiments using two different techniques to prevent activity in the gene, both approaches prevented the biological processes associated with tooth resorption.

Researchers say their findings, published in Scientific Reports, suggest that the MMP9 gene, and the protein it generates, are involved in causing tooth resorption. Blocking the action of this particular gene could, therefore, prevent the cell processes that lead to disease, they write.

Dr Seungmee Lee from the Royal (Dick) School of Veterinary Studies, explains: “This is a painful condition which affects virtually all mature cats, and currently there is no effective way to manage the disease other than removing affected teeth. By examining genes involved in the process it seems that if we stop the activity of the MMP9 gene, we may be able to prevent the condition from developing.” 

Currently, there are no treatments for tooth resorption other than extracting the affected teeth. Researchers say their discovery could inform new treatments for this condition and may also have implications for other conditions, such as the role of MMP9 in bone diseases.

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RCVS Fellowship applications open

News Story 1
 Applications have now opened for RCVS Fellowship 2022. The RCVS is encouraging anyone who would like to be considered for Fellowship to apply, and if successful, they will be welcomed into the Fellowship next year.

The process for joining the fellowship has changed slightly for this year, as applicants will now need two signed referee forms instead of three professional references, and five assessors will review each application instead of three.

The deadline for applications is 14 February 2022, and more information on how to apply can be found here. If applicants have any questions, or would like informal advice from previous successful applicants, they are encouraged to contact Ceri Via Email 

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Horiba announces veterinary haematology webinar

Horiba Medical has announced a free webinar providing practical insight on best practice in veterinary haematology. Entitled 'In practice haematology - Beyond the pale!' the webinar will be presented by Ronnie Barron from the University of Glasgow Veterinary School.

Ronnie's presentation, which will conclude with a Q&A session, will look at QC and artefacts of sample quality and review the effects of different pathologies. Using images, photomicrographs and video links, he will also explain the techniques and equipment needed to complement analytical automation to confirm results quality.

The webinar takes place on Thursday, October 28 (7.30-9pm). For more details and to register, click here.